● Giant cell tumor.

0

○ 작성자: 서경진

○ 고유번호: 4152

○ 분류: 연부, 골, 피부세포병리

○ 장기: 연부조직

○

○ Atypical, favor neoplastic

Atypical, favor neoplastic

○ 설명

Male, 25 years
Right distal femur.
Right distal femur pathologic fracture

● Giant cell tumor.

0

○ 작성자: 서경진

○ 고유번호: 4151

○ 분류: 연부, 골, 피부세포병리

○ 장기: 연부조직

○ 도말세포

○ Atypical, favor neoplastic

Atypical, favor neoplastic

○ 설명

Male, 25 years
Right distal femur.
Right distal femur pathologic fracture

● Atypia of Undetermined Significance Other; exclusively oncocytic cells.

1

○ 작성자: 홍순원

○ 고유번호: 4128

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Atypia of Undetermined Significance

Atypia of Undetermined Significance

○ 설명

59/F

Atypia of Undetermined Significance (TBSRTC Category III)
Other; The sample consists exclusively of oncocytic cells.

Note: In a patient with follicular nodular disease, the findings likely represent a oncocytic cell hyperplasia, but a oncocytic cell neoplasm cannot be entirely excluded. Clinical correlation is advised.

Final diagnosis: Oncocytic adenoma 

● Benign follicular nodular disease

0

○ 작성자: 홍순원

○ 고유번호: 4131

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Benign

Consistent with a benign follicular nodule disease

○ 설명

56/F

Benign (TBSRTC Category II)
Consistent with follicular nodular disease accoring to  2022 WHO classification of thyroid tumors (includes previously designated as colloid nodule, hyperplastic nodule, adenomatous nodule, or benign follicular nodule )
Scanty cellularity

Final diagnosis; Adenomatous hyperplasia

● Nondiagnostic Cell paucity

0

○ 작성자: 홍순원

○ 고유번호: 4130

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Nondiagnostic

Virtually acellular specimen

○ 설명

43/F

Nondiagnostic (TBSRTC Category I )
Cell paucity
A few inflammatory cells only

core biopsy; PAPILLARY CARCINOMA 

Final diagnosis; PAPILLARY CARCINOMA 

● Suspicious for papillary carcinoma

0

○ 작성자: 홍순원

○ 고유번호: 4129

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Suspicious for malignancy

Suspicious for papillary carcinoma

○ 설명

32/ F

Suspicious for malignancy (TBSRTC Category V)
- Suspicious for papillary carcinoma

Final diagnosis; PAPILLARY CARCINOMA

● Suspicious for papillary carcinoma

0

○ 작성자: 홍순원

○ 고유번호: 4127

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 도말세포

○ Suspicious for malignancy

Suspicious for papillary carcinoma

○ 설명

25/F

Suspicious for malignancy (TBSRTC Category V)
- Suspicious for papillary carcinoma

● Atypia of Undetermined Significance Nuclear atypia; A few follicular cells with subtle nuclear atypia

0

○ 작성자: 홍순원

○ 고유번호: 4126

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Atypia of Undetermined Significance

Atypia of Undetermined Significance

○ 설명

24/F

Atypia of Undetermined Significance (TBSRTC Category III)
Nuclear atypia;  A few follicular cells with subtle nuclear atypia

Note: 대부분은 hemosiderin laden macrophage로써 adenomatous hyperplasia에 동반된 change로 생각되지만, 함께 도말된 소수의 follicular cell의 핵의 atypia가 약하게 있고 단단한 결집력을 보여 NIFTP에 cystic change가 있는 경우를 배제할 수 없습니다.  임상적인 소견을 참고하셔서 진단하시길 바랍니다.

Follow up cytology; Suspicious for malignancy (TBSRTC Category V)
- Suspicious for papillary carcinoma in the backgound of hemorrahgic cystic smear
 

● Atypia of Undetermined Significance Nuclear atypia; subtle nuclar atypia and focal architectural atypia?

0

○ 작성자: 홍순원

○ 고유번호: 4125

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Atypia of Undetermined Significance

Atypia of Undetermined Significance

○ 설명

24/F 

Atypia of Undetermined Significance (TBSRTC Category III)
Nuclear atypia; Relatively moderate cellularity follicular cells; some show subtle nuclar atypia and focal architectural atypia. 

Note: The possibility of Follicular neoplasm or NIFTP should be ruled out. A repeat aspirate after an appropriate interval of observation may be helpful if clinically indicated.

Follow up cytology; Suspicious for malignancy (TBSRTC Category V)
- Suspicious for papillary carcinoma in the backgound of hemorrahgic cystic smear
 

● Atypia of Undetermined Significance Nuclear atypia; focal nuclear atypia

0

○ 작성자: 홍순원

○ 고유번호: 4124

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 도말세포

○ Atypia of Undetermined Significance

Atypia of Undetermined Significance

○ 설명

44/F

Atypia of Undetermined Significance (TBSRTC Category III)
Nuclear atypia; focal nuclear atypia

Note:대부분 세포는 benign follicular cell로 구성되어 있으나 일부 cell cluster가 nuclear enlargement, pale chromatin, and irregular nuclear contour를 보여 악성의 가능성을 배제할 수 없습니다. 조직학적 검사로 확인하는 것이 좋겠습니다.

● Hyalinizing trabecular tumor

0

○ 작성자: 홍순원

○ 고유번호: 4123

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 도말세포

○ Suspicious for malignancy

Suspicious for malignancy, other

○ 설명

50/F

Suspicious for malignancy (TBSRTC Category V)
- Suspicious for papillary carcinoma, see note

Note; 종양세포는 spindle cell로 구성되어 있고 nuclear inclusion이 자주 관찰되어 papillary carcinoma로 생각되지만, Hyalinizing trabecular tumor의 가능성을 배제해야할 것으로 생각합니다. spindle cell에 atypia가 있어 anaplastic carcinoma를 생각해볼 수는 있으나 전반적으로 tumor diathesis의 소견이 없어 가능성은 적을 것으로 생각합니다.

Final diagnosis: Hyalinizing trabecular tumor 

● MEDULLARY THYROID CARCINOMA

1

○ 작성자: 홍순원

○ 고유번호: 4121

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 도말세포

○ Malignant

Medullary thyroid carcinoma

○ 설명

58/M

MALIGNANT (TBSRTC Category VI)
MEDULLARY THYROID CARCINOMA

Final diagnosis; MEDULLARY CARCINOMA
 

● MEDULLARY THYROID CARCINOMA

1

○ 작성자: 홍순원

○ 고유번호: 4122

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 도말세포

○ Malignant

Medullary thyroid carcinoma

○ 설명

63/M

Lymph node, right, level 3, 

POSITIVE FOR MALIGNANCY, METASTATIC MEDULLARY THYROID CARCINOMA

Final diagnosis;  METASTATIC MEDULLARY CARCINOMA
 

● Follicular Neoplasm-Oncocytic Follicular Neoplasm

0

○ 작성자: 홍순원

○ 고유번호: 4120

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Follicular Neoplasm

Follicular neoplasm, Hurthle cell (oncocytic) type

○ 설명

55/ F

Follicular Neoplasm-Oncocytic Follicular Neoplasm (TBSRTC Category IV)

Final diagnosis
Thyroid gland, left lobe: Oncocytic Follicular Adenoma
 

● Follicular Neoplasm-Oncocytic Follicular Neoplasm

0

○ 작성자: 홍순원

○ 고유번호: 4119

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Follicular Neoplasm

Follicular neoplasm, Hurthle cell (oncocytic) type

○ 설명

32/F

Follicular Neoplasm-Oncocytic Follicular Neoplasm (TBSRTC Category IV)
Relatively hypercellular oncocytic cells; some show subtle nuclar atypia and focal architectural atypia. 

Note: The possibility of Oncocytic follicular neoplasm, NIFTP or FVPTC should be ruled out.

● Atypia of Undetermined Significance Other

0

○ 작성자: 홍순원

○ 고유번호: 4118

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 도말세포

○ Atypia of Undetermined Significance

Atypia of Undetermined Significance

○ 설명

49/F

Atypia of Undetermined Significance (TBSRTC Category III)
Other; 
Microcalcific debris with few multinucleated giant cells and sparse degenerated follicular cells are seen.
Note: Microcalcific debris mimicking psammomatous calcification are associated with both benign and malignant thyroid aspirates including papillary thyroid carcinoma.
Clinical and radiologic correlation and follow-up are recommended.

Follow up cytology; Benign 
Suggestive of granulomatous (subacute) thyroiditis see note

Note: Benign follicular cell clusters, Lymphocytes, mucltinucleated giant cell로 구성된 smear 소견입니다. 외부슬라이드에서 언급된 psammoma body는 관찰되지 않고 colloid aggregates로 생각되는 물질이 관찰되어, 상기 smear 소견을 고려하면 granulomatous (subacute) thyroiditis의 가능성이 높을 것으로 생각합니다. 

● Nondiagnostic Cell paucity

0

○ 작성자: 홍순원

○ 고유번호: 4117

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Nondiagnostic

Virtually acellular specimen

○ 설명

50/ F

Nondiagnostic (TBSRTC Category I )
Cell paucity
Rare follicular cells, see note

Note; 보내온 검체에는 10개이상의 follicular cell로 구성된 cluster가 관찰되지 않습니다.

Final diagnosis: Adenomatous hyperplasia with extensive calcifiation and fibrosis
 

● Atypia of Undetermined Significance, Nuclear and architectural atypia

0

○ 작성자: 홍순원

○ 고유번호: 4116

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Atypia of Undetermined Significance

Atypia of Undetermined Significance

○ 설명

57/F 
조직진단; PAPILLARY CARCINOMA: Follicular variant, encapsulated with capsular invasion

● Suspicious for Malignancy, papillay carcinoma

0

○ 작성자: 홍순원

○ 고유번호: 4115

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Suspicious for malignancy

Suspicious for papillary carcinoma

● Nondiagnostic, foreign material, muscle?

0

○ 작성자: 홍순원

○ 고유번호: 4114

○ 분류: 내분비계세포병리

○ 장기: 갑상선

○ 액상세포

○ Nondiagnostic

Other (obscuring blood, clotting artifact, etc.)